大连医科大学附属第一医院

曲佳琳

曲佳琳
所属科室:
中西医结合基础
职称:
研究员
出诊时间:
专家介绍:
(1)专家简介 曲佳琳,女,博士,研究员,硕士生导师。2019和2022年先后入选大连市“青年才俊”和“高端人才”。2008年毕业于沈阳药科大学,获药学学士学位;2014年于同校获中药学博士学位(硕博连读)。2012~2013年赴日本京都药科大学生药学研究室进行博士研修。现为辽宁省中医药学会药物研发专业委员会常务委员,中华中医药学会中成药和中药基础理论分会、辽宁省药学会中药和天然药物专业委员会委员。兼任《Chinese Medicine》《Chinese Herbal Medicine》《Acta Materia Medica》和《沈阳药科大学学报》等期刊青年编委。 作为课题负责人主持国家自然科学基金2项(面上和青年各1项),中国博士后科学基金面上项目1项,辽宁省自然科学基金2项,辽宁省教育厅服务地方项目1项,大连市医学科学研究计划项目1项,大连医科大学重点实验室开放基金2项,大医一院-大连化物所联合基金1项。另外,作为项目骨干成员参与国家重点研发计划项目1项,国家自然科学基金3项,辽宁省重点研发计划2项,中华医学会教改课题1项。 2021年获辽宁省科技进步二等奖(排名:2),2022年获大连市科技进步三等奖(排名:4),2023年获中国中西医结合学会科学技术奖一等奖(排名:11),2012年获辽宁省自然科学学术成果特等奖(排名:4),2014年获沈阳市自然科学学术成果奖(排名:2)。近年来在Pharmacological Research, International Journal of Biological Macromolecules, Journal of Ethnopharmacology, Chinese Medicine等期刊以第一/通讯作者(含共同)身份发表SCI论文28篇,单篇最高10.5分。 (2)研究方向 1. 中药质量评价和活性成分体内代谢研究 2. 肝胆胰疾病防治中药体内外活性成分筛选及作用机理研究 (3)在研项目 1. 基于“肠道菌-肝脏PPARα”联动维持脂质稳态的“以脾调肝”行为探究葛花缓解酒精性肝损伤的作用机制,国家自然科学基金面上项目,2026/01~2029/12,主持 2. 肠道菌代谢活化的海藻寡糖抗胰腺癌候选药物研发,大医附一-大连化物所“医工联合创新基金”一般项目,2025/05~2027/05,主持 (4)代表文章 1. Yanan Li, Jinghong Li, Aijing Leng, Guixin Zhang*, Jialin Qu*. Cardiac complications caused by biliary diseases: A review of clinical manifestations, pathogenesis and treatment strategies of cholecardia syndrome. Pharmacological Research. 2024, 199: 107006(通讯作者, IF202410.5) 2. Yan Liu, Kangzhe Fu, Aijing Leng, Lin Zhang, Jialin Qu*, Spotlight on the accumulation of heavy metals in Traditional Chinese medicines: A holistic view of pollution status, removal strategies and prospect. Science of the Total Environment. 2024:176025(通讯作者, IF20248.0) 3. Yuankuan Jiang, Shumeng Zhang, Hewen Guan, KejiaLv, Jinchao Yu, Siyi Li, Renchuan Jia, Xiujie Zhang, Shurong Ma, Jialin Qu*, Jingrong Lin*. Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis. Chinese Medicine. 2026; 21(1): 18(通讯作者, IF20245.7) 4. Jieyu Shen, Tianfu Wei, Mingchen Li, Yuankuan Jiang, Jiahui Zhang, Yueyi Qi, Cai Chen, Xiaojie Li, Peng Huang, Jialin Qu*. Aloe vera-derived extracellular vesicle-like particles suppress pancreatic carcinoma progression through triggering pyroptosis via ROS-GSDMD/E signaling pathway. Chinese Medicine. 2025; 20(1): 101(通讯作者, IF2024 5.7) 5. Wenqian Duan, Mingchen Cai, Qiqi Ma, Peng Huang, Jiahui Zhang, Tianfu Wei, Dong Shang, Aijing Leng*,Jialin Qu*. Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway. Chinese Medicine. 2024,19(1): 29(通讯作者, IF20245.7) 6. Jiahui Zhang, Siyi Li, Yueyi Qi, Jieyu Shen, Aijing Leng*, Jialin Qu*. Animal-derived peptides from Traditional Chinese medicines: medicinal potential, mechanisms, and prospects. Journal of Ethnopharmacology. 2025; 349: 119872(通讯作者, IF20245.4) 7. Chengru Li, Haiqing Wang, Kangzhe Fu, Aijing Leng, Jialin Qu*. Violae Herba: A comprehensive review of the traditional uses, phytochemistry, pharmacology, quality control and clinical applications. Journal of Ethnopharmacology. 2025; 119561(通讯作者, IF20245.4) 8. Cai Chen#, Xiaojie Li#, Yoshihiro Kano, Dan Yuan*, Jialin Qu*. Oriental traditional herbal Medicine--Puerariae Flos: A systematic review. Journal of Ethnopharmacology. 2023,306: 116089(通讯作者, IF20245.4) 9. Jialin Qu, Qiuyue Chen, Tianfu Wei, Ning Dou, Dong Shang*, Dan Yuan*. Systematic characterization of Puerariae Flos metabolites in vivo and assessment of its protective mechanisms against alcoholic liver injury in a rat model. Frontiers in Pharmacology. 2022, 13:915535(第一作者, IF20225.988) 10. Tian-Fu Wei#,Liang Zhao#,Peng Huang,Feng-Lin Hu,Ju-Ying Jiao, Kai-Lai Xiang, Zhi-Zhou Wang,JiaLin Qu*,Dong Shang*. Qing-Yi Decoction in the Treatment of Acute Pancreatitis: An Integrated Approach Based on Chemical Profile, Network Pharmacology, Molecular Docking and Experimental Evaluation. Frontiers in Pharmacology. 2021, 12:590994(通讯作者, IF20215.988) (5)招生专业 中西医结合基础;药学 (6)联系方式 电子邮箱: jialin_qu@126.com