大连医科大学附属第一医院

魏敏

魏敏
所属科室:
中西医结合基础
职称:
研究员
出诊时间:
专家介绍:
(1)专家简介 魏敏,博士,研究员,大连市高层次人才-青年才俊。毕业于中国科学院上海应用物理研究所。2013年11月-至今,大连医科大学附属第一医院-神经疾病研究所工作。主要从事纳米生物学及神经生物学交叉研究,具体研究方向为环境因素对神经发育、老化以及包括阿尔茨海默病和帕金森病在内的神经退行性病变的影响机制,以及通过仿生纳米药物对神经退行性疾病的创新治疗研究等,获得国家自然科学基金青年项目1项,以第一作者在Angew. Chem. Int. Ed.,Small,Journal of Nanobiotechnology等国际权威杂志上发表多篇文章。 (2)研究方向 1. 脑靶向仿生纳米智能药物的设计及用于神经退行性疾病的治疗 2. 环境因素对神经退行性疾病发生发展的影响及机制研究 (3)在研项目 辽宁省科学技术厅, 辽宁省科技计划联合计划(自然科学基金-面上项目), 2025-MSLH-187, 基于肠-肺轴探讨知母多糖调节肺炎小鼠肠道微生态和免疫功能的研究,2025-11 至 2027-10, 8万元,在研,第二参与人。 (4)代表文章 1. Hu, Y., Yang, Z., Wang, X., Li, X. & Wei, M. Oxidative Stress and Lysosomal Dysfunction in Neurodegenerative Diseases: Underlying Mechanisms and Nanotherapeutic Targeting Strategies. Antioxidants (Basel). 2026, 15(1).(通讯作者,SCI,IF=6.6) 2. Wei, M.; Li, W.; Bao, G.; Yang, Z.; Li, S.; Le, W. PM2.5 exposure exacerbates Alzheimer's disease pathology through lysosomal dysfunction in APP/PS1 mice. Ecotoxicology and environmental safety. 2025, 303, 118918. (共同第一作者&共同通讯作者,SCI,IF=6.1) 3.MinWei, Zhaofei Yang, Song Li, Weidong Le*. Nanotherapeutic and Stem Cell Therapeutic Strategies in Neurodegenerative Diseases: A Promising Therapeutic Approach, International journal of nanomedicine. 2023,18, 611-626.(第一作者,SCI,IF=7.033) 4. Min Wei#*, Guangming Bao#, Song Li, ZhaofeiYang, Cheng Cheng,Weidong Le*. PM2.5 exposure triggers cell death through lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells. Ecotoxicology and environmental safety 2022, 248, 114333. (共同第一作者&共同通讯作者,SCI,IF=7.129) 5. Min Wei, Song Li, Zhaofei Yang, Cheng Cheng, Tianbai Li, Weidong Le*.Tetrahedral DNA nanostructures functionalized by multivalent microRNA132 antisense oligonucleotides promote the differentiation of mouse embryonic stem cells into dopaminergic neurons. Nanomedicine : nanotechnology, biology, and medicine. 2021, 34, 102375. (第一作者,SCI,IF=6.458) 6.Min Wei, Song Li, Zhaofei Yang, Wei Zheng, Weidong Le*. Gold nanoparticles enhance the differentiation of embryonic stem cells into dopaminergic neurons via mTOR/p70S6K pathway. Nanomedicine (Lond). 2017, 12(11): 1305-1317. (第一作者,SCI,IF=5.005 ) 7.Min Wei, Song Li, Weidong Le*. Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms. Journal of Nanobiotechnology. 2017, 15:75. (第一作者,SCI,IF=5.294) 8.Wei Zheng#, Min Wei#, Song Li, Weidong Le*. Nanomaterial-modulated autophagy: underlying mechanisms and functional consequences. Nanomedicine (Lond), 2016, 11(11), 1417-1430. (共同第一作者,SCI,IF=4.727) 9.Nan Chen#, Min Wei#, Yanhong Sun, Fan Li, Hao Pei, Shao Su, Yao He, Lianhui Wang, Jiye Shi, Chunhai Fan*, Qing Huang*. Self-assembly of poly-adenine-tailed CpG oligonucleotide-gold nanoparticle nanoconjugates with immunostimulatory activity. Small, 2014, 10(2): 368-375. (共同第一作者,SCI,IF=8.368) 10.Min Wei#, Nan Chen#, Jiang Li, Min Yin, Le Liang, Yao He, Haiyun Song, Chunhai Fan*, and Qing Huang*, Polyvalent immunostimulatory nanoagents with self-assembled CpG oligonucleotide-conjugated gold nanoparticles, Angew. Chem. Int. Ed., 2012, 51: 1202-1206. (第一作者,SCI,IF=13.734) (5)招生专业 神经病学(学术型) (6)联系方式 weimin0411@163.com