- 首页
- 专家介绍
刘晶
- 所属科室：
- 中西医结合基础
- 职称：
- 教授
- 出诊时间：
- 专家介绍：
- 刘晶，女，1970生人，二級教授，博士研究生导师，牛津大学博士后。大连医科大学附属第一医院党委书记，大连干细胞与精准医学创新研究院院长。国家首批干细胞临床研究机构、国家级国际科技合作基地、国家地方联合工程实验室和国家基因检测示范中心主任。担任国际神经修复学会（IANR）脑性瘫痪分会主席，辽宁省干细胞临床研究专家委员会主任委员。享受国务院政府特殊津贴，全国三八红旗手，辽宁省特聘教授，辽宁省首批“学术头雁”，辽宁省“青年名医”。全国首个备案“神经干细胞治疗小儿脑瘫临床研究”项目负责人，国家干细胞临床研究项目评审专家。主持科技部国际科技合作重大专项、国家首批干细胞临床研究项目、国防科技创新特区等科研项目20余项，经费2000余万元。在Molecular Cancer、Oncogene、ACS Applied Materials Interfaces等期刊发表论文100余篇，总影响因子超350，申请及授权专利20余项。
研究方向：
1.针对危害人民健康的重大疾病的疾病特异性干细胞移植规范化方案研究；干细胞相关技术如干细胞分离纯化技术、体内示踪技术、植入技术和相关设备研发，并推出疾病特异性干细胞技术工程包。
2.针对目前干细胞移植的关键性瓶颈问题，通过国际合作方式，引进技术，最终推出器官、修复病灶、细胞三特异性干细胞定植支架及定向生长分化关键技术，解决制约干细胞治疗重大疾病的关键性技术问题。
3.基于干细胞与三维组织工程技术构建的中药活性成分筛选平台，包括：神经损伤修复的中药天然活性产物筛选；针对神经退行性病变的中药天然活性产物筛选；抗肿瘤复发及迁移的中药筛选及机制研究等。
在研项目：
1) 国家卫计委与食药监局：干细胞治疗小儿脑性瘫痪的临床研究[批准号：CMR-20161129-1003号]，立项时间：2017.7-2021年12月，资助金额：500万，主持人：刘晶
2) 国防科技创新特区：干细胞对病毒性肺炎的治疗及康复作用研究[批准号：19-163-00-KX-003-001-01号]，立项时间：2020.3-2020.9，资助金额：60万，主持人：刘晶
3) 辽宁省项目： 干细胞神经损伤修复关键技术[批准号：XLYC1902031号]，立项时间：2020.1.1-2022.12.31，资助金额：100万，主持人：刘晶
4) 大连市科技创新基金：临床级干细胞技术研发及在小儿脑瘫中的临床研究[批准号：2018J11CY025号]，立项时间：2019.1.1-2021.12.30，资助金额：300，主持人：刘晶
代表文章(*为通讯作者，IF＞5分) ：
1. Wang Liang, Li Ying, Guan Xin, Zhao Jingyuan, Shen Liming, Liu Jing. Exosomal double-stranded DNA as a biomarker for the diagnosis and preoperative assessment of pheochromocytoma and paraganglioma, MOLECULAR CANCER, 2018, 17: 128. IF= 27.401
2. Ying Li#, Liang Wang#, Jing Liu*, Pengxin Zhang, Meng An, Chao Han, Yuxiang Li, Xin Guan, Kun Zhang. O-GlcNAcylation modulates Bmi-1 protein stability and potential oncogenic function in prostate cancer, ONCOGENE, 2017, 36(45): 6293-6305. IF= 9.867
3. Liu Lijie, Zhang Xiuli, Liu Xi, Liu, Jing*, Lu Guozhong, Kaplan, David L. Zhu Hesun, Lu Qiang*. Biomineralization of Stable and Monodisperse Vaterite Microspheres Using Silk Nanoparticles, ACS APPLIED MATERIALS & INTERFACES, 2015, 7(3): 1735-1745. IF= 9.229
4. Qu Chao, Ma Jingyun, Zhang Yejun, Han Chao, Huang Liang, Shen Liming, Li Hongyan, Wang Xiaobo, Liu Jing*, Zou Wei*. Estrogen receptor variant ER-alpha 36 promotes tamoxifen agonist activity in glioblastoma cells, CANCER SCIENCE, 2019, 110(1): 221-234. IF= 6.716
5. Sheng Weiqin#, Liu Jing#, Liu Shanshan, Lu Qiang, Kaplan David L, Zhu Hesun. One-step synthesis of biocompatible magnetite/silk fibroin core-shell nanoparticles, JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2(42): 7394-7402. IF= 6.331
6. Shen Li-Ming, Liu Jing*. New development in carbon quantum dots technical applications, TALANTA, 2016, 156: 245-256. IF= 6.057
7. Jia Wang, Yanhong Ma, Jingshi Yang, Lu Jin, Zixiang Gao, Lingyun Xue, Lin Hou, Linlin Sui*, Jing Liu*, Xiangyang Zou*, Fucoxanthin inhibits tumour-related lymphangiogenesis and growth of breast cancer, J Cell Mol Med. 2019, 23: 2219–2229. IF= 5.31
8. Yang Jiao, Yue-Tong Sun, Nai-Fei Chen, Li-Na Zhou, Xin Guan, Jia-Yi Wang, Wen-Juan Wei, Chao Han, Xiao-Lei Jiang, Ya-Chen Wang, Wei Zou, Jing Liu, Human UC-MSCs promote plasticity repair in prenatal maternal immune astrocyte activation-associated neonatal brain injury by inhibiting expression of PTBP-1, Neural regeneration research, Accepted, IF= 5.135
9. Yang Jiao, Yu-Wan Liu, Wei-Gong Chen, Jing Liu*, Neuroregeneraton and functonal recovery afer stroke: advancing neural stem cell therapy toward clinical applicaton, NEURAL REGENERATION RESEARCH, 2021, 16(1):80-92. IF= 5.135
10. Zhong-Yue Lv, , Ying Li, Jing Liu*, Progress in clinical trials of stem cell therapy for cerebral palsy, NEURAL REGENERATION RESEARCH, 2021, 16(1). IF= 5.135
11. Chao Han, , Ya-Jun Wang, Ya-Chen Wang, Xin Guan, Liang Wang, Li-Ming Shen, Wei Zou, Jing Liu*, Caveolin-1 downregulaton promotes the dopaminergic neuron-like diferentaton of human adipose-derived mesenchymal stem cells, NEURAL REGENERATION RESEARCH, 2021, 16(4): 714-720. IF= 5.135
12. Wen-Juan Wei, Bei Shi, Xin Guan, Jing-Yun Ma, Ya-Chen Wang, Jing Liu, Mapping theme trends and knowledge structures for human neural stem cells: a quantitative and co-word biclustering analysis for the 2013–2018 period, NEURAL REGENERATION RESEARCH, 14(10):1823-1832. IF= 5.135
13. Liu Yong, Liu Lei, Ying Xi-xiang, Wei Wen-juan, Han Chao, Liu Yang, Han Chun-hui, Leng Ai-Jing, Ma Jing-yun, Liu Jing*. Dried Rehmannia root protects against glutamate-induced cytotoxity to PC12 cells through energy metabolism-related pathways, NEURAL REGENERATION RESEARCH, 2017, 12(8): 1338-1346. IF= 5.135
14. Li Xiao-yan, Liang Zhan-hua, Han Chao, Wei Wen-juan, Song Chun-li, Zhou Li-na, Liu Yang, Li Ying, Ji Xiao-fei, Liu Jing*. Transplantation of autologous peripheral blood mononuclear cells in the subarachnoid space for amyotrophic lateral sclerosis: a safety analysis of 14 patients, NEURAL REGENERATION RESEARCH, 2017, 12(3): 493-498. IF= 5.135
15. Yin Yan, Zhou Xiang, Guan Xin, Liu Yang, Jiang Chang-bin, Liu Jing*, In vivo tracking of human adipose-derived stem cells labeled with ferumoxytol in rats with middle cerebral artery occlusion by magnetic resonance imaging, NEURAL REGENERATION RESEARCH, 2015, 10(6):909-915. IF= 5.135
16. Liu Yang, Liang Zhanhua, Liu Jing, Zou Wei, Li Xiaoyan, Wang Yachen, An Lijia*, Down regulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats, NEURAL REGENERATION RESEARCH, 2013, 8(29): 2725-2733. IF= 5.135
17. Li-Ming Shen, Linglai Quan, Jing Liu*. Tracking Exosomes in Vitro and in Vivo To Elucidate Their Physiological Functions: Implications for Diagnostic and Therapeutic Nanocarriers, ACS Applied Nano Materials, 2018, 1(6): 2438-2448. IF= 5.097
招生专业： 神经病学；中西医结合基础
